This book targets the key issues of both research and practice in innovation and strategic management fields and is regarded as one of the important works explaining enterprises from the innovation system perspective. The book is based on the existing literature involving national innovation system, regional innovation system, and industrial/sectional innovation system and reviews intra-organizational innovation system researches and inter-organizational innovation ecosystem literature. Accordingly, the book proposes a “core competence-based innovation ecosystem framework”, indicating the importance of fit between firms' internal core competence and external innovation ecosystem, which is pivotal for leveraging the sustainable competitiveness advantages. In addition, the book further adopts multiple case studies, involving the firms' innovation ecosystems upon ten typical global enterprises in and out of China – e.g., Apple Inc., Siemens, Procter & Gamble, Microsoft Corporation, Google, Founder Group, Haier Group, China South Railway, Huawei, and Midea. Teachers and researchers from universities in innovation and strategic management fields and industrial management practitioners can benefit from the book.