The Fourth Industrial Revolution means the widespread digitization of economic processes using more economical and efficient production technologies. Orientation towards productivity, flexibility and low production costs results in a slow process of dehumanization of industry and focus only on implementing digital technologies of Industry 4.0. A natural consequence of this trend is the concern of workers, governments and societies about new challenges and the role of humans in industry and the economy. The hope is the emergence of a new industry concept proposed by the European Commission that expands the features of the existing Industry 4.0 concept to include human-centric, environmental and resilience aspects in smart organizations. Industry 5.0 is an excellent alternative to the development of today’s digital and dehumanized world, and this book presents challenges and priority directions for smart organizations in an environment shaped by the pillars of Industry 5.0. This research volume discusses the development of technologies that support human-oriented work systems, sustainable production and system resilience in intelligent organizations. It presents an educational challenge for universities and vocational schools in preparing employees for intelligent organizations and will be of interest to researchers, academics, policymakers, and students in the fields of organizational studies, knowledge management and the digital economy.