Drawing on the findings of the most ambitious national study to date on nonprofit strategic restructuring, the authors provide nonprofit managers, board members, consultants, and foundation executives with research-based information to use in making tough decisions about whether and how to pursue a range of organizational partnerships—from jointly managed programs and consolidated administrative functions to full-scale mergers. The authors investigate two widespread assumptions—that strategic restructuring leads to greater organizational efficiency and that nonprofit consolidations are similar to corporate consolidations. Six in-depth case studies of actual nonprofit restructurings highlight the costs and benefits associated with this increasingly adopted course of action, a trend that is expected to remain on the upswing for the foreseeable future.